重组鸭肠炎病毒载体疫苗研究进展

doi:10.11843/j.issn.0366-6964.2017.11.002

摘要/Abstract

摘要：

重组病毒载体疫苗是一种以减毒活病毒为载体承载表达其他病原抗原性基因的新型疫苗，能感染宿主细胞、递呈外源基因所表达的抗原蛋白、诱导机体产生体液免疫应答和细胞免疫应答，从而有效地预防多种疾病。鸭肠炎病毒基因组长约160 kb，包含多个非编码区和病毒复制非必需区，可携带多个或较大的外源基因，是构建重组活病毒疫苗的理想载体。随着分子生物学研究的不断深入和分子生物学实验技术的飞速发展，对鸭肠炎病毒基因组进行遗传修饰的技术手段已十分成熟，目前已通过这些技术成功构建了多株重组鸭肠炎病毒活载体疫苗。研究表明构建的重组鸭肠炎病毒活载体疫苗可成功抵抗鸭肠炎病毒和其他相应病原的攻击，具有作为重组病毒疫苗载体的潜力，并在未来的禽类新型疫苗研制中发挥重要作用。本文对以鸭肠炎病毒作为载体的重组病毒活载体疫苗的研究进展进行综述，以期为鸭肠炎病毒载体疫苗的研发提供参考。

Abstract:

Recombinant virus-vectored vaccine is a newly developed vaccine based on viral vectors delivering protective antigens of other pathogens. It can infect host cells and deliver antigen protein encoded by exogenous genes, stimulating both humoral and cellular immune responses. Duck enteritis virus (DEV) has a large genome about 160 kb in length, containing large amounts of non-encoding region and nonessential replication region. Recombinant genetic engineering techniques have brought forward a leap in molecular biology study of DEV and designing DEV-vectored vaccines. Recent studies have demonstrated that DEV may be a promising viral vector candidate and plays a crucial role in future vaccine development. In this review, we summarized the advances of studies on recombinant DEV-vectored vaccines to provide some valuable fundamental information for future DEV vaccine development.

中图分类号:

S852.659.1

马云潮, 程安春, 汪铭书, 吴英. 重组鸭肠炎病毒载体疫苗研究进展[J]. 畜牧兽医学报, 2017, 48(11): 2015-2022.

MA Yun-chao, CHENG An-chun, WANG Ming-shu, WU Ying. Progress of Recombinant Duck Enteritis Virus-vectored Vaccines[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(11): 2015-2022.

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